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. 2021 Dec 2;141(1):127–146. doi: 10.1007/s00439-021-02394-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — PHEWAS-based clustering of mtDNA-CN associated SNPs. UMAP clusters created from PHEWAS associations for mtDNA-CN associated SNPs. A Three clusters were identified as labeled in the panel; orange indicates no cluster. B–F SNPs are colored based on their effect estimate size, standardized to the effect on mtDNA-CN (red = positive, blue = negative estimates), for B platelet count, C mean platelet volume, D platelet distribution width, E serum calcium levels, F mean spherical cellular volume