Table 2.
The comparison between the subjects’ BMI at baseline with those at 6 months (T6) and 12 months (T12) and its relationship with genetic variants
| p-value | ||||||
|---|---|---|---|---|---|---|
| FTO rs9939609 T > A | TT | TA | AA | Genotypea | Timeb | Interactionc |
|
Baseline T6 T12 |
33.3 (27.7, 38.0) 36.5 (27.8, 37.2) 31.5 (26.6, 35.8) |
31.3 (28.5, 35.6) 30.6 (28.0, 35.1) 30.4 (27.8, 34.6) |
36.7 (33.1, 37.7) 38.0 (33.5, 38.2) 36.1 (32.1, 37.2) |
0.907 | < 0.001 | 0.056 |
| MC4R rs17782313 T > C | TT | TC | CC | Genotypea | Timeb | Interactionc |
|
Baseline T6 T12 |
29.4 (28.4, 36.7) 29.5 (27.9, 36.2) 28.2 (27.0, 35.3) |
31.9 (31.3, 36.7) 31.6 (30.6, 38.0) 31.9 (30.4, 36.1) |
42.6 (40.3, 44.9) 41.6 (39.4, 43.7) 40.8 (38.0, 43.6) |
0.077 | < 0.001 | 0.175 |
| LPL rs326 A > G | AA | AG | GG | Genotypea | Timeb | Interactionc |
|
Baseline T6 T12 |
28.7 (28.2, 37.9) 32.2 (27.1, 37.6) 27.8 (26.1, 36.0) |
29.6 (28.2, 35.9) 29.5 (27.3, 35.6) 29.1 (27.1, 34.7) |
38.6 (31.9, 41.3) 38.3 (31.6, 40.3) 36.9 (31.9, 38.3) |
0.162 | < 0.001 | 0.966 |
| NPY rs16147 C > T | CC | CT | TT | Genotypea | Timeb | Interactionc |
|
Baseline T6 T12 |
28.7 (28.4, 30.3) 29.8 (28.9, 30.7) 27.8 (27.0, 29.8) |
35.6 (29.0, 38.3) 35.1 (28.4, 38.2) 34.6 (28.1, 36.5) |
– | 0.251 | 0.004 | 0.662 |
| IRS-1 rs2943641 C > T | CC | CT | TT | Genotypea | Timeb | Interactionc |
|
Baseline T6 T12 |
31.3 (28.7, 36.7) 31.1 (27.9, 37.4) 30.4 (26.1, 35.1) |
35.6 (28.2, 37.9) 35.1 (28.0, 36.5) 34.6 (27.9, 36.0) |
34.2 (29.4, 40.8) 34.1 (28.8, 40.2) 34.2 (28.7, 40.4) |
0.653 | < 0.001 | 0.342 |
Data are expressed as median and interquartile range. Probability that the effect of nutritional intervention on BMI is influenced by:
a time, for each variable, the differences have been tested between baseline, T6 and T12 of the three Genotypes
b groups, for each variable, the differences have been tested between Genotypes over time
c Probability that the effects of nutritional intervention is greater in one distinct group (interaction Time *genotype)