Table 5.

The comparison between the subjects’ total cholesterol at baseline with those at 6 months (T6) and 12 months (T12) and its relationship with genetic variants

				p-value
FTO rs9939609 T > A	TT	TA	AA	Genotypea	Timeb	Interactionc
Baseline T6 T12	212.0 (197.0, 224.8) 205.0 (196.0, 212.0) 195.5 (189.2, 202.5)	199.0 (176.5, 203.2) 199.0 (198.0, 252.0) 176.0 (159.5, 209.8)	222.0 (213.5, 234.5) 243.0 (233.0, 253.0) 243.0 (233.0, 253.0)	0.332	0.859	0.214
MC4R rs17782313 T > C	TT	TC	CC	Genotypea	Timeb	Interactionc
Baseline T6 T12	207.5 (199.2, 224.8) 198.0 (195.0, 217.5) 198.0 (168.2, 218.2)	199.0 (183.0, 201.0) 257.0 (228.0, 260.0) 176.0 (164.0, 200.8)	204.0 (197.5, 210.5) 228.5 (216.8, 240.2) 221.0 (204.5, 237.5)	0.614	0.669	0.283
LPL rs326 A > G	AA	AG	GG	Genotypea	Timeb	Interactionc
Baseline T6 T12	199.0 (196.0, 201.0) 225.0 (218.5, 241.0) 158.0 (151.0, 204.0)	210.0 (195.5, 226.5) 198.0 (195.0, 214.0) 195.5 (189.2, 198.0)	205.0 (199.0, 217.0) 225.5 (212.2, 238.8) 225.0 (186.0, 254.0)	0.894	0.660	0.347
NPY rs16147 C > T	CC	CT		Genotypea	Timeb	Interactionc
Baseline T6 T12	199.0 (197.5, 199.0) 225.0 (225.0, 225.0) 166.0 (155.0, 185.0)	207.5 (193.2, 223.5) 205.0 (197.0, 237.5) 198.0 (186.0, 225.0)		0.729	0.199	0.161
IRS-1 rs2943641 C > T	CC	CT	TT	Genotypea	Timeb	Interactionc
Baseline T6 T12	201.0 (196.0, 225.0) 223.0 (202.0, 241.0) 198.5 (187.5, 223.5)	199.5 (185.8, 206.0) 203.0 (198.5, 207.5) 154.5 (149.2, 168.0)	207.5 (193.0, 211.8) 198.0 (165.5, 225.0) 226.0 (188.5, 256.2)	0.416	0.609	0.058

Data are expressed as median and interquartile range. Probability that the effect of nutritional intervention on total cholesterol is influenced by:

^a time, for each variable, the differences have been tested between baseline, T6 and T12 of the three Genotypes

^b groups, for each variable, the differences have been tested between Genotypes over times

^c Probability that the effects of nutritional intervention is greater in one distinct group (Time *genotype)