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. 2022 Jan 13;12:656. doi: 10.1038/s41598-021-04562-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Activation of Nrf2 by oral streptococci inhibited the NFĸB signalling pathway. Raw 264.7 cells were pre-treated with 10 µM ML385 for 24 h prior to infection with oral streptococci. (a) Raw 264.7 cells stably transfected with the ARE SEAP reporter were infected with S. mitis or S. oralis. The expression of (b) HO-1 was determined by qRT-PCR. (c) Raw 264.7 cells stably transfected with the NFĸB SEAP were infected with bacteria. The expression of (d) TNF-α and (e) IL-1β were determined by qRT-PCR. ***p < 0.001.