Table 2.
Frequency of PIK3CA, TP53, and GATA3 driver mutations in previously reported DCIS studies and pure DCIS in this study.
| Gene | Pang et al. 2017 (N = 20) | Lin et al. 2019 (N = 65) | Nagasawa et al. 2021 (N = 72) | Pareja et al. 2020 (N = 7) | This study | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Alla | Grade | Histology | ||||||||
| Low | Inter.-high | Cribriform | Solid | Other | ||||||
| PIK3CA | 55% | 40% | 50% | 0% | 43% (10/23) | 29% (2/7) | 50% (8/16) | 55% (6/11) | 40% (4/10) | 0% (0/2) |
| TP53 | 30% | 13.8% | 21% | 14.3% | 31.3% (5/16) | 0% (0/4) | 41.7% (5/12) | 33.3% (3/9) | 40% (2/5) | 0% (0/2) |
| GATA3 | 45% | 13.8% | 56% | 28.6% | 20% (3/15) | 75% (3/4) | 0% (0/13) | 33.3% (2/6) | 0% (0/9) | 50% (1/2) |
aThe denominator represents samples with at least 20x coverage across the targeted regions.