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. 2022 Jan 13;12:685. doi: 10.1038/s41598-021-04682-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Degranulation is associated with the production of LDNs. (A) MPO concentrations in healthy controls and sepsis patients. (B) MMP9 concentrations in healthy controls and sepsis patients. (C) Changes of LDNs in PBMC layer after stimulation of neutrophils with various concentrations of LPS. (D) MPO concentration in the supernatants of neutrophils stimulated by LPS or PMA. (E) MMP9 concentration in the supernatants of neutrophils stimulated by LPS or PMA. (F, G) Correlation analysis of LDNs ratio and degranulation components.