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. 2022 Jan 13;8:7. doi: 10.1038/s41523-021-00374-x

Fig. 7. Summary model of the reciprocal HBXIP/Nrf2 feedback loop in breast cancer cells.

Fig. 7

HBXIP induces anoikis resistance in breast cancer cells by forming a reciprocal positive feedback loop with Nrf2 to maintain redox homeostasis, inhibiting JNK1 activation by preventing Prdx1 ubiquitination.