. 2022 Jan 13;12:688. doi: 10.1038/s41598-021-03837-0

Table 2.

Fold change in cytokine levels induced by non-viable B. burgdorferi over live bacteria induced levels.

2A: Frontal cortex tissues
Animal 1	7.81*** (± 0.13)	1.37* (± 0.04)	6.28*** (± 0.003)
Animal 2	10.83** (± 0.44)	2.90** (± 0.08)	13.67*** (± 0.59)
Animal 3	0.26** (± 0.02)	0.66 (± 0.18)	0.23** (± 0.05)
Animal 4	2.51* (± 0.23)	0.89 (± 0.25)	3.79** (± 1.11)
Animal 5	3.39** (± 0.06)	2.10 (± 0.21)	15.03 (± 2.79)

2A: Frontal cortex tissues

CCL2

CXCL8

IL-6

Animal 1

7.81***

(± 0.13)

1.37*

(± 0.04)

6.28***

(± 0.003)

Animal 2

10.83**

(± 0.44)

2.90**

(± 0.08)

13.67***

(± 0.59)

Animal 3

0.26**

(± 0.02)

0.66

(± 0.18)

0.23**

(± 0.05)

Animal 4

2.51*

(± 0.23)

0.89

(± 0.25)

3.79**

(± 1.11)

Animal 5

3.39**

(± 0.06)

2.10

(± 0.21)

15.03

(± 2.79)

2B: DRG tissues
Animal 3	0.88 (± 0.18)	1.09 (± 0.17)	2.73* (± 0.04)
Animal 4	1.15 (± 0.16)	0.40* (± 0.02)	0.52* (± 0.04)
Animal 5	1.30** (± 0.02)	1.58** (± 0.03)	1.33* (± 0.02)

2B: DRG tissues

DRG

CCL2

CXCL8

IL-6

Animal 3

0.88

(± 0.18)

1.09

(± 0.17)

2.73*

(± 0.04)

Animal 4

1.15

(± 0.16)

0.40*

(± 0.02)

0.52*

(± 0.04)

Animal 5

1.30**

(± 0.02)

1.58**

(± 0.03)

1.33*

(± 0.02)

Fold change was calculated as levels induced by non-viable B. burgdorferi divided by those induced by live bacteria. Values were calculated from levels in Figs. 1 and 2. Numbers greater than 1 indicate higher levels induced by non-viable bacteria, while those less than one indicates higher levels induced by live bacteria. Values that are bold and underlined indicate statistically significant increase in non-viable Borrelia induced levels, while those in bold and italics indicates statistically significant lower levels, compared to those induced by live bacteria. Other values indicate no statistically significant difference. Standard deviation is shown with in brackets. FC frontal cortex, DRG Dorsal root ganglion. *p < 0.05, **p < 0.01, ***p < 0.001.