. 2022 Jan 13;12:688. doi: 10.1038/s41598-021-03837-0

Table 3.

Other significantly induced chemokines/cytokines in the FC and DRG by live and non-viable B. burgdorferi.

3A: Frontal cortex tissues
FGF2	3441.9 (± 64.8)	*2596.72* (± 96.63)	*4603.59* (± 190.93)	7851.2 (± 702.54)	4184.45 (± 167.83)	5705.9 (± 461.10)	2304.24 (± 53.56)	*1837.52* (± 60.68)	2197.53 (± 4.67)	1935.10 (± 28.50)
GCSF	ND	ND	ND	ND	164.01 (± 10.56)	117.89 (± 0.00)	24.68 (± 8.13)	33.66 (± 4.57)	ND	60.73 (± 6.70)
IL-1β	11.69 (± 0.87)	4.76 (± 0.62)	11.13 (± 0.90)	27.99 (± 0.17)	21.91 (± 1.82)	14.18 (± 1.68)	38.99 (± 1.34)	22.55 (± 2.27)	42.93 (± 2.00)	55.42 (± 2.25)
IL-18	22.75 (± 1.15)	14.25 (± 0.98)	11.69 (± 0.25)	16.16 (± 0.38)	16.34 (± 1.32)	9.61 (± 0.98)	78.66 (± 1.64)	91.40 (± 3.27)	25.20 (± 1.32)	60.90 (± 1.34)
IL-1RA	447.1 (± 5.12)	506.95 (± 9.07)	214.10 (± 50.95)	853.16 (± 30.98)	*581.95* (± 67.60)	852.12 (± 29.51)	78.53 (± 41.17)	120.23 (± 42.37)	344.09 (± 20.4)	170.68 (± 31.54)
MIP1α	8.74 (± 0.06)	7.76 (± 0.23)	11.00 (± 0.06)	29.28 (± 0.26)	18.29 (± 0.61)	32.24 (± 1.14)	45.11 (± 1.37)	36.49 (± 0.90)	50.46 (± 2.07)	92.29 (± 6.10)
SCF	6.66 (± 0.06)	5.20 (± 1.01)	8.02 (0.00)	10.51 (± 0.65)	3.97 (± 0.20)	3.64 (± 0.66)	3.26 (± 0.93)	3.17 (± 0.0)	3.17 (0.00)	3.265 (± 0.13)

3A: Frontal cortex tissues

Animal 1

Animal 2

Animal 3

Animal 4

Animal 5

Live

FGF2

3441.9

(± 64.8)

2596.72

(± 96.63)

4603.59

(± 190.93)

7851.2

(± 702.54)

4184.45

(± 167.83)

5705.9

(± 461.10)

2304.24

(± 53.56)

1837.52

(± 60.68)

2197.53

(± 4.67)

1935.10

(± 28.50)

GCSF

164.01

(± 10.56)

117.89

(± 0.00)

24.68

(± 8.13)

33.66

(± 4.57)

60.73

(± 6.70)

IL-1β

11.69

(± 0.87)

4.76

(± 0.62)

11.13

(± 0.90)

27.99

(± 0.17)

21.91

(± 1.82)

14.18

(± 1.68)

38.99

(± 1.34)

22.55

(± 2.27)

42.93

(± 2.00)

55.42

(± 2.25)

IL-18

22.75

(± 1.15)

14.25

(± 0.98)

11.69

(± 0.25)

16.16

(± 0.38)

16.34

(± 1.32)

9.61

(± 0.98)

78.66

(± 1.64)

91.40

(± 3.27)

25.20

(± 1.32)

60.90

(± 1.34)

IL-1RA

447.1

(± 5.12)

506.95

(± 9.07)

214.10

(± 50.95)

853.16

(± 30.98)

581.95

(± 67.60)

852.12

(± 29.51)

78.53

(± 41.17)

120.23

(± 42.37)

344.09

(± 20.4)

170.68

(± 31.54)

MIP1α

8.74

(± 0.06)

7.76

(± 0.23)

11.00

(± 0.06)

29.28

(± 0.26)

18.29

(± 0.61)

32.24

(± 1.14)

45.11

(± 1.37)

36.49

(± 0.90)

50.46

(± 2.07)

92.29

(± 6.10)

SCF

6.66

(± 0.06)

5.20

(± 1.01)

8.02

(0.00)

10.51

(± 0.65)

3.97

(± 0.20)

3.64

(± 0.66)

3.26

(± 0.93)

3.17

(± 0.0)

3.17

(0.00)

3.265

(± 0.13)

3B: DRG tissues
DRG	Animal 3		Animal 4		Animal 5
DRG	Live	NV	Live	NV	Live	NV
FGF2	748.74 (± 9.51)	913.16 (± 63.45)	357.88 (± 0.90)	242.96 (± 7.57)	597.49 (± 4.82)	*344.91* (± 4.83)
GCSF	606.96 (± 15.43)	815.59 (± 15.88)	231.3 (± 2.97)	190.14 (± 6.33)	57.15 (0.00)	60.3 (± 14.85)
IL-1β	11.42 (± 0.33)	2.44 (± 0.08)	8.875 (± 0.66)	11.13 (± 0.08)	3.495 (± 0.25)	1.31 (± 0.35)
IL-17A	18.33 (± 0.34)	2.135 (± 0.76)	13.72 (± 3.46)	12.99 (± 3.12)	11.76 (± 2.78)	11.27 (± 2.10)
IL-1RA	ND	ND	111.00 (± 28.91)	224.14 (± 12.46)	ND	ND
MIP1α	30.83 (± 0.89)	20.91 (± 2.18)	42.71 (± 0.30)	47.11 (± 2.20)	5.06 (± 0.04)	12.22 (± 0.95)
SCF	7.40 (± 0.45)	6.00 (± 0.51)	1.61 (± 0.50)	1.92 (± 0.31)	1.66 (± 0.32)	0.74 (± 0.21)
VEGF	63.34 (± 7.79)	71.97 (± 6.07)	*47.58* (± 3.14)	*17.19* (± 0.83)	6.955 (± 1.35)	25.81 (± 2.54)

Numbers indicate pg/mL of each chemokine/cytokine with standard deviation in brackets. Significantly higher levels than medium controls are bold and underlined, while those in bold and italics indicate significantly lower levels than medium levels. Other numbers indicate no significant change compared to medium controls. FC Frontal cortex, DRG dorsal root ganglion, ND not detected by the multiplex kit. NV non-viable B. burgdorferi.