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. 2022 Jan 13;13:321. doi: 10.1038/s41467-021-27869-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Volcano plot of genes altered in inguinal subcutaneous white adipose tissue from control and Ad-Tmem120a^−/− female mice on HFD (n = 5). b Gene Ontology (GO) Biological Process analysis for downregulated genes. GO terms found to be significantly enriched using g:Profiler fall into four classes: metabolism (beige), development (brown), transport (green) and response to stimulus (blue). The bars represent the proportion of genes associated with each individual enriched GO term that are present in the downregulated genes dataset. c Gene ontology (GO) Biological Process of analysis for upregulated genes. All of the enriched GO terms are related to muscle function, either skeletal (dark red) or cardiac (pale red). The bars represent the proportion of genes associated with each individual enriched GO term that are present in the upregulated genes dataset. d Tissue-specific gene enrichment for upregulated genes in iWAT from Ad-Tmem120a^−/− mouse by TissueEnrich tool presented as fold enrichment. Source data are provided as a Source Data file.