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Illustration of the “Phoenix Rising” pathway of wound healing and tissue regeneration. Damage in tissues leads to the activation of Caspase 3/7, which cleaves and activates iPLA2 and increased production of arachidonic acid, a precursor for the production of PGE2, a known stimulating signal for stem cell growth and tissue regeneration. From Li et al, Science Signaling, 2010, PMID: 20179271.
