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. 2021 Dec 22;17(1):96–109. doi: 10.1016/j.stemcr.2021.11.009

Figure 5.

Figure 5

Multi-electrode array recordings confirming synaptic connectivity via dosage with NBQX and LTP induction

(A) Representative waveforms of spontaneous activity on a single electrode on day 75 during pre (left) and post dosage (right) with 25 μM NBQX.

(B) Graphical representation of neuronal firing rates normalized to baseline activity before and after control 0.1% DMSO or 25 μM NBQX dose.

(C) Graph of normalized firing rates of control dose of 0.1% DMSO and following LTP stimulation immediately and 1 h after dosage, normalized to post-dose, pre-LTP baseline.

(D) Graph of normalized firing rates for 25 μM NBQX dosed and following LTP stimulation immediately and 1 h after dosage, normalized to post-dose, pre-LTP baseline. Statistical analysis was performed using a Kruskal-Wallis test followed by Dunn's multiple comparisons test; ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001. Error bar: SEM. N = 10 electrodes from three individual experiments.