Figure 7.

The induction and quieting of epileptiform activity via dosage with bicuculine and valproic acid in immature (21 DIV) cortical neurons

(A) Waveform representations of baseline activity (left), 100 μM bicuculline-dosed (middle), and 1 mM valproic acid dosed (right) systems.

(B) Graphical representation of the immature firing rates normalized to baseline. Statistical analysis was performed using one-way ANOVA followed by Tukey's test; ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001. Error bar: SEM. N = 10 electrodes from three individual experiments.