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. 2022 Jan 11;17(1):127–142. doi: 10.1016/j.stemcr.2021.12.005

Figure 6.

Figure 6

Neuronal activity inhibition of engrafted cells affected the locomotor function and electrophysiological parameters in long-term-followed animals

(A) BMS scores before CNO administration, after CNO administration, and after CNO washout (mCherry-TP group, n = 8; hM4Di-TP group, n = 10).

(B) Representative images of MEP waves in mCherry-TP animals and hM4Di-TP animals (left, pre-CNO; right, post-CNO).

(C) Average of normalized maximal amplitude in mCherry-TP group and hM4Di-TP group (mCherry-TP group, n = 6; hM4Di-TP group, n = 6).

(D) Average of normalized peak latency in mCherry-TP group and hM4Di-TP group (mCherry-TP group, n = 6; hM4Di-TP group, n = 6). ∗p < 0.05 according to the Wilcoxon signed rank test following Friedman test (A) and the Mann-Whitney U test (C and D). The data are presented as the mean ± SEM (A, C, and D). All multiple testing data analyses were followed by Bonferroni correction.