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. 2022 Jan;192(1):121–129. doi: 10.1016/j.ajpath.2021.09.009

Figure 1.

Figure 1

A–D: Histopathology (hematoxylin and eosin) (A and B), immunohistochemistry (C), and RNAscope in situ hybridization (D) of cervix associated with EBOV infection. A: Acute ectocervicitis: the lamina propria is expanded and infiltrated by hemorrhage, edema, and numerous degenerate neutrophils with increased squamous epithelial desquamation in a female macaque 6 days after exposure. Scale bar: 100 μm. B: EBOV intracytoplasmic inclusion bodies (arrows) are observed in the fibroblast cells in the lamina propria from a female macaque 7 days after exposure. Scale bar: 50 μm C: Immunohistochemistry shows that many stromal cells and macrophages in the interstitium of an endocervical gland are strongly EBOV-VP40–antigen positive from a female macaque 6 days after exposure. Scale bar: 100 μm. D: RNAscope in situ hybridization confirms that many stromal cells and macrophages (arrowheads) of lamina propria and a few squamous epithelial cells (arrows) in an ectocervix are strongly EBOV–genomic RNA positive from a female macaque 6 days after exposure. Scale bar: 50 μm.