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. 2022 Jan;192(1):121–129. doi: 10.1016/j.ajpath.2021.09.009

Figure 2.

Figure 2

A–D: Histopathology (hematoxylin and eosin) (A), immunohistochemistry (B and C), and RNAscope in situ hybridization (D) of vagina associated with EBOV infection. A: Acute hemorrhagic vaginitis and microthrombosis (arrows) are present in a female macaque 7 days after exposure. Scale bar: 100 μm. B and C: Immunohistochemistry shows that many submucosal macrophages and stromal cells (arrowheads) and squamous epithelial cells (arrows) are strongly EBOV-VP40–antigen (B) and EBOV-GP–antigen (C) positive from two female macaques, 6 and 8 days, respectively, after exposure. Scale bars: 100 μm and 50 μm, respectively. D: RNAscope in situ hybridization shows that many submucosal macrophages and stromal cells (arrowheads) and squamous epithelial cells (arrows) are strongly EBOV–genomic RNA positive from a female macaque 8 days after exposure. Scale bar: 50 μm.