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. 2022 Jan;192(1):121–129. doi: 10.1016/j.ajpath.2021.09.009

Figure 4.

Figure 4

A–D: Histopathology (hematoxylin and eosin) (A), immunohistochemistry (B and C), and RNAscope in situ hybridization (D) of the adrenal medulla from EBOV-infected macaques. A: A macaque 7 days after exposure shows acute medullary adrenalitis characterized by hemorrhage and many lymphoplasmacytic and histiocytic infiltrates in the adrenal medulla. Scale bar: 50 μm. B and C: Immunohistochemistry shows that many chromaffin cells (arrows) in the medulla are EBOV-VP40–antigen (B) and EBOV-GP–antigen (C) positive from two macaques, 6 and 7 days, respectively, after exposure. Scale bars: 50 μm. D: RNAscope in situ hybridization confirms that many chromaffin cells (arrows) in the adrenal medulla are EBOV–genomic RNA positive. Scale bar = 50 μm.