Table 1.

Total Number of m⁶A Peaks in the Murine Liver and Their Alterations in M3LKO Mice

m6A peaks in M3LKO mice	mRNA				lncRNA
	5′-UTR	Exon	3′-UTR	Total
Reduced	253	2251	2461	4965	384
Increased	589	1405	1127	3121	196
No change	233	1323	1208	2764	174
Total	1075	4979	4796	10,850	754

The total number of peaks (transcript sequences) that were identified in the wild-type liver that exhibited m⁶A enrichment in immunoprecipitated RNA with the m⁶A-specific antibody compared with input RNA are given. Enrichment of these sites were then compared in M3LKO versus WT mice to identify differential peaks.

lncRNA, long noncoding RNA; M3LKO, liver-specific Mettl3 knockout.