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. 2022 Jan;192(1):160–177. doi: 10.1016/j.ajpath.2021.10.003

Figure 5.

Figure 5

Transmission electron microscopy (TEM) showing increased abnormal mitochondria in Sigmar1−/− mice skeletal muscles. A–E: Representative TEM images of gastrocnemius (Gastro; A), quadriceps (Quad; B), tibialis anterior (TA; C), soleus (Sol; D), and extensor digitorum longus (EDL; E) muscle sections from wild-type (Wt) and Sigmar1−/− mice. All muscles examined were isolated from age-matched 9- to 10-month–old littermate Wt and Sigmar1−/− mice. F: Bar graphs represent relative mitochondrial DNA (mtDNA)/nuclear DNA (nDNA) ratio measured by comparing mtDNA content to total genomic DNA (nDNA) in Gastro, Quad, TA, Sol, and EDL muscles from 9- to 10-month–old Wt and Sigmar1−/− mice. Dots in the bar graphs represent individual values quantified for each muscle. Data are expressed as fold change with respect to Wt mice. Data are expressed as means ± SEM (F). n = 3 mice per genotype (A–E); n = 4 mice per muscle per group (F). Scale bars = 5 μm (A–E).