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. 2021 Dec 1;122(1):565–788. doi: 10.1021/acs.chemrev.1c00449

Scheme 393. Shape-Persistent Macrocycles Containing peri-Condensed Pyridine Rings.

Scheme 393

Reagents and conditions: (a)331 NH4OAc, dioxane/mesitylene (1:4, v/v) 150 °C, 5 days; (b) R1-Br, NaH, THF, 65 °C, 2 days.