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. 2021 Dec 1;122(1):565–788. doi: 10.1021/acs.chemrev.1c00449

Scheme 394. Sulfur-Containing peri-Fused Macrocycles.

Scheme 394

Reagents and conditions: (a)775 acetylene, Pd(PPh3)4, CuI, Et3N, THF, 70 °C, 3 h; (b)774,775 Na2S·H2O, toluene, 2-methoxyethanol, 150 °C, 12 h; (c)775 TFA, DCM, H2O, rt, 12 h; (d)775p-TsOH, AcOH, EtOH, DCM, 110 °C, 12 h.