Table 4.

Association of markers of inflammation and endothelial activation across all children with severe anemia and P falciparum parasitemia

	N obs, n event	HR	95% CI	P *	HR, adjusted for age and Hb genotype	95% CI, adjusted for age and Hb genotype	P *
Risk of death or readmission†
Angpt-2, pg/mL	186, 49	1.45	0.77, 2.72	.25	1.48	0.75, 2.92	.25
TNF-α, pg/mL	212, 57	0.54	0.36, 0.81	.003	0.55	0.36, 0.83	.004
l-arg/ADMA ratio	165, 48	2.24	0.56, 8.91	.25	2.67	0.64, 11.1	.18
Risk of malaria outpatient visit†
Angpt-2, pg/mL	186, 81	1.83	1.09, 3.06	.02	2.03	1.14, 3.59	.016
TNF-α, pg/mL	212, 88	1.29	0.81, 2.06	.28	1.33	0.82, 2.15	.25
l-arg/ADMA ratio	165, 75	1.44	0.46, 4.47	.53	1.77	0.55, 5.72	.34

Association of markers of inflammation and endothelial activation associated with SCA and risk of readmission or death and risk of malarial outpatient visit within 24 months across all children with severe anemia and P falciparum parasitemia.

N obs, number observed.

^*Significant P values in bold, determined by FDR = 0.05.

^†Cox regression is based on log10 transformation of biomarkers, so HR is increase in outcome for each log10 increase in biomarker.