Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Effects of PARP inhibition. PARPis are able to create their own interaction network with proteins outside the nucleus, beside the sole blockage of PARP (on target action of PARPis). By inducing signaling pathways and impacting secondary proteins, they can affect cell functions and cause metabolic responses that constitute the off-target actions of PARPi.
