Table 3.
Bivariable and multivariable Cox-regression of predictor variable among children living with HIV at South Gondar hospitals, Ethiopia, 2021(n = 363)
| Exposure variable | SAM NO Yes |
CHR (95% CI) | AHR (95% CI) | P-Value | ||
|---|---|---|---|---|---|---|
| Age of the child (years) | ≤3 | 71 | 24 | 1.0 (0.63–1.78) | – | |
| > 4–10 | 96 | 35 | 1.0 (0.64–1.60) | |||
| > 10 | 99 | 38 | Ref | |||
| Sex | Male | 144 | 46 | 0.7 (0.47–1.05) | 0.9 (0.56–1.32) | 0.487 |
| Female | 122 | 51 | Ref | Ref | ||
| Residence | Rural | 51 | 22 | 1.2 (0.79–1.78) | – | |
| Urban | 215 | 75 | Ref | |||
| Caregiver’s Marital status | Married | 175 | 63 | 1.2 (0.37–3.78) | – | |
| Widowed | 79 | 27 | 1.1 (0.34–3.76) | – | ||
| Divorced | 7 | 3 | Ref | |||
| Caregiver’s status | Both alive | 186 | 63 | Ref | ||
| Either or Bothe died | 80 | 34 | 1.1 (0.71–1.65) | – | ||
| Caregiver’s occupational status | Housewife | 145 | 58 | 0.8 (0.35–1.70) | – | |
| Governmental employee | 66 | 23 | 0.7 (0.30–1.67) | – | ||
| Merchant | 29 | 9 | 0.8 (0.28–2.07) | – | ||
| Non-governmental employee | 26 | 7 | Ref | |||
| HIV status of the Caregiver’s | Positive | 218 | 63 | 0.5 (0.29–0.83) | 0.6 (0.32–1.01) | 0.053 |
| Negative | 23 | 15 | 0.9 (0.46–1.84) | 0.4 (0.18–1.01) | 0.054 | |
| Not Known | 25 | 19 | Ref | Ref | ||
| Disclosure status | Yes | 135 | 54 | Ref | Ref | |
| No | 131 | 43 | 1.3 (0.86–1.92) | 1.6 (0.98–2.47) | 0.057 | |
| Regimen at baseline | PI-based | 12 | 24 | 3.0 (1.90–4.82) | 0.9 (0.50–1.61) | 0.715 |
| Non-PI based | 254 | 73 | Ref | Ref | ||
| Treatment failure | Yes | 6 | 33 | 4.3 (2.81–6.57) | 3.4 (2.05–5.75) | 0.000 |
| No | 260 | 64 | Ref | Ref | ||
| Cotrimoxazole preventive therapy | Yes | 24 | 39 | Ref | Ref | |
| No | 242 | 58 | 3.5 (2.30–5.19) | 1.6 (0.96–2.65) | 0.070 | |
| CD4 counts or % | Below threshold | 19 | 42 | 3.9 (2.62–5.85) | 2.5 (1.64–3.95) | 0.000 |
| Above threshold | 247 | 55 | Ref | Ref | ||
| Isoniazid preventive therapy (IPT) | Yes | 125 | 31 | Ref | Ref | |
| No | 141 | 66 | 1.3 (0.85–2.02) | 0.8 (0.49–1.26) | 0.327 | |
| ART adherence | Good | 203 | 77 | Ref | ||
| Poor/Fair | 63 | 20 | 0.8 (0.49–1.32) | |||
| TB status | Yes | 12 | 28 | 3.7 (2.37–5.75) | 1.2 (0.68–2.27) | 0.471 |
| No | 254 | 69 | Ref | Ref | ||
| Hx of OIs other than TB (n = 319) | Yes | 85 | 32 | 1.1 (0.68–1.64) | – | |
| No | 149 | 53 | Ref | |||
| Hemoglobin level | < 10 mg/dl | 19 | 30 | 2.4 (1.55–3.71) | 1.6 (0.75–1.95) | 0.433 |
| > = 10 mg/dl | 247 | 67 | Ref | Ref | ||
| WHO stages | Stage I&II | 239 | 43 | Ref | Ref | |
| Stage III&IV | 27 | 54 | 4.8 (3.18–7.11) | 2.9 (1.74–4.73) | 0.000 | |
| Duration On ART | < 49 months | 131 | 57 | 0.9 (0.6–1.4) | – | |
| ≥49 months | 135 | 40 | Ref | |||
*Significant at < 0.05; ** Significant at < 0.01; CHR Crude hazard ratio, AHR Adjusted hazard ratio, Ref Reference category, CI Confidence interval