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. 2020 May 6;23(1):101–119. doi: 10.1093/biostatistics/kxaa017

Table 2.

Simulation results: performance measures of regression parameter estimated using pseudo-observation and a model with identity link function and an independence working covariance matrix for the number of LYL due to cancer and due to other causes. The explanatory variables were age at diagnosis, sex, and year of diagnosis. Results based on 500 simulated data sets with different sample sizes (N=300,1000).

Cause Covariate LFP Inline graphic Bias (Inline graphic) empSE ModSE RMSE CoverageInline graphic
    Inline graphic Inline graphic Inline graphic Inline graphic Inline graphic Inline graphic Inline graphic Inline graphic Inline graphic Inline graphic Inline graphic Inline graphic
Cancer Age 0.553 0.542 0.55 −10.029 −2.559 0.179 0.097 0.177 0.097 0.18 0.097 0.948 0.948
Sex 0.749 0.8 0.777 50.949 28.345 0.569 0.318 0.573 0.319 0.572 0.319 0.954 0.95
Year −0.002 −0.002 −0.003 −0.133 −1.913 0.322 0.17 0.321 0.172 0.322 0.17 0.954 0.956
Other causes Age 0.49 0.489 0.502 −0.737 12.319 0.045 0.025 0.049 0.028 0.045 0.027 0.968 0.964
Sex 0.223 0.273 0.235 49.817 12.618 0.134 0.07 0.139 0.077 0.143 0.071 0.934 0.974
Year −0.021 0.011 −0.037 31.802 −15.82 0.084 0.047 0.085 0.047 0.09 0.05 0.932 0.92

LFP, least false parameter; empSE, empirical standard error; ModSE, model standard error; RMSE, root mean squared error.

Inline graphic Acceptable coverage range is calculated as Inline graphic