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. 2022 Jan 14;4(1):zcab051. doi: 10.1093/narcan/zcab051

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© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Cell-type specific miRNAs provide insight into the cellular composition of tissues. (A) Heatmap illustrating the expression of 25 cell-specific miRNAs for each tissue that had mean expression >100 RPM in at least one tissue. The color scale indicates the z-score of RPM for each miRNA. (B) PCA plot based on analysis of 25 cell-specific miRNA with expression >100 reads per million, VST normalized, colored by tissue. Transparent points are individual samples, solid points represent the statistical mean and shaded ellipses is 95% confidence of the mean of each tissue. (C) The correlation circle shows PCA loadings, which are the direction and relative contribution the top 15 cell-type specific miRNAs had on clustering of each tissue. Reads per million (RPM); principal component analysis (PCA); varianceStabilizingTransformation (VST); primary colorectal cancer (pCRC); normal colorectal tissue (nCR); CRC liver metastasis (mLi); normal adjacent liver tissue (nLi); CRC lung metastasis (mLu); normal adjacent lung tissue (nLu); CRC peritoneal metastasis (PM).