Table 1.
Differentially expressed miRNAs in mCRC compared to pCRC according to metastatic site. Reads per million (RPM); log2 fold change (LFC) estimated using DESeq2; standard error (SE); primary colorectal cancer (pCRC); normal colorectal tissue (nCR); CRC liver metastasis (mLi); normal adjacent liver tissue (nLi); CRC lung metastasis (mLu); normal adjacent lung tissue (nLu); CRC peritoneal metastasis (PM); false discovery rate (FDR)
| mLi vs pCRC | mLu vs pCRC | PM vs pCRC | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| MirGeneDB ID (miRBase ID) | pCRC RPM | RPM | LFC (SE) | FDR | RPM | LFC (SE) | FDR | RPM | LFC (SE) | FDR |
| Mir-191_5p | 13630 | 23253 | 0.74 (0.15) | 3.67E-06 | 26989 | 0.74 (0.16) | 9.81E-06 | 20429 | 0.61 (0.15) | 2.42E-04 |
| Mir-210_3p | 291 | 685 | 1.26 (0.18) | 4.73E-11 | 693 | 1.15 (0.19) | 1.55E-08 | 491 | 0.71 (0.18) | 3.37E-04 |
| Mir-1307_5p | 492 | 887 | 0.85 (0.17) | 2.99E-06 | 797 | 0.62 (0.17) | 8.29E-04 | |||
| Mir-8-P1b_3p (mir-141–3p) | 7518 | 11957 | 0.64 (0.19) | 4.07E-03 | 15111 | 0.75 (0.21) | 1.12E-03 | |||
| Mir-155_5p | 387 | 733 | 0.76 (0.18) | 7.24E-05 | 654 | 0.70 (0.17) | 1.59E-04 | |||
| Mir-10-P1a_5p (mir-10a-5p) | 97123 | 164925 | 0.86 (0.19) | 8.04E-05 | ||||||
| Mir-592_5p | 75 | 137 | 0.98 (0.27) | 4.88E-03 | ||||||
| Mir-1247_5p | 69 | 127 | 0.85 (0.28) | 2.58E-02 | ||||||
| Mir-425_5p | 700 | 1117 | 0.73 (0.12) | 2.90E-08 | ||||||
| Mir-486_5p | 2013 | 1489 | -0.66 (0.23) | 3.47E-02 | ||||||
| Mir-142_5p | 3453 | 7117 | 0.84 (0.18) | 2.01E-05 | ||||||
| Mir-19-P2a/P2b_3p | 1297 | 2345 | 0.80 (0.15) | 9.38E-07 | ||||||
| Mir-374-P1_5p | 115 | 217 | 0.72 (0.12) | 9.07E-09 | ||||||
| Mir-19-P1_3p | 379 | 597 | 0.65 (0.16) | 3.42E-04 | ||||||
| Mir-423_5p | 433 | 202 | -1.17 (0.17) | 1.35E-10 | ||||||
| Let-7-P1b_5p | 1057 | 650 | -0.86 (0.16) | 2.55E-07 | ||||||
| Mir-197_3p | 181 | 113 | -0.74 (0.13) | 1.76E-07 | ||||||
| Mir-92-P1c_3p | 1398 | 981 | -0.72 (0.18) | 2.22E-04 | ||||||
| Mir-362-P2/P4_3p | 441 | 302 | -0.65 (0.14) | 2.36E-05 | ||||||
| Mir-221-P2_3p | 1633 | 1101 | -0.60 (0.14) | 8.50E-05 | ||||||
| Mir-506-P3_3p | 6 | 112 | 2.69 (0.29) | 6.35E-09 | ||||||
| Mir-506 P4a1/P4a2/P4b_3p | 14 | 191 | 2.72 (0.29) | 5.75E-11 | ||||||
| Mir-154-P9_3p | 253 | 455 | 0.85 (0.14) | 1.43E-08 | ||||||
| Mir-127_3p | 2263 | 2888 | 0.61 (0.20) | 1.42E-02 | ||||||
| Mir-154-P36_3p | 195 | 330 | 0.74 (0.13) | 7.13E-07 | ||||||
| Mir-223_3p | 619 | 280 | -0.94 (0.21) | 4.62E-05 | ||||||