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. 2022 Jan 13;11(1):2025668. doi: 10.1080/2162402X.2022.2025668

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Radiotherapy plus camrelizumab remodel TCR diversity.

(a) Changes of Shannon index, clonality and Simpson’s index during combination treatment. (b) Intratumoral clonotypes identified at baseline expanded or contracted in on-treatment tumors. (c) Intratumoral expansion of persistent clonotypes during treatment was associated with patient survival. (d) Intratumoral clonotypes identified at baseline expanded or contracted in peripheral CD8⁺ T cells during treatment. Expanded, TCR frequency higher in on-treatment tumors (b and c) or in on-treatment peripheral blood (d) compared with their corresponding samples at baseline. Contracted, TCR frequency lower in on-treatment tumors (b) or in on-treatment peripheral blood (d) compared with their corresponding samples at baseline. RTT, intratumoral T cells after 40 Gy radiation and 2 rounds of camrelizumab. RTC, peripheral CD8⁺ T cells after 40 Gy radiation and 2 rounds of camrelizumab. N = 15 paired tumor tissues (a-c), 18 paired peripheral CD8⁺ T cells (a), and 17 (d). P < .05, significant difference.