Table 3.
Univariate analysis of pre-operative clinical predictive factors on speech intelligibility change off- and on-medication and perceptual rating (DAB scale) change one year after STN-DBS (N=54).
| Outcome Variable | Predictive Variable | B-coefficient | P< |
|---|---|---|---|
| Change in speech intelligibility AIDS pre-off to one year off/on | AIDS pre-on | −1.8 | 0.0001 |
| AIDS pre-off | −2.5 | 0.01 | |
| UPDRS-III pre-on | 0.75 | 0.23 | |
| UPDRS-III pre-off | 0.78 | 0.004 | |
| Duration of PD | 2.77 | 0.001 | |
| Age at surgery | 0.08 | 0.87 | |
| Change in speech intelligibility AIDS pre-on to one year on/on | AIDS pre-on | 0.31 | 0.52 |
| AIDS pre-off | −3.99 | 0.0001 | |
| UPDRS-III pre-on | 0.68 | 0.24 | |
| UPDRS-III pre-off | 0.51 | 0.03 | |
| Duration of PD | 1.99 | 0.004 | |
| Age at surgery | 0.30 | 0.51 | |
|
| |||
| Change in DAB scale pre-off to one year off/on | AIDS pre-on | −0.43 | 0.001 |
| AIDS pre-off | −0.99 | 0.41 | |
| UPDRS-III pre-on | 0.23 | 0.18 | |
| UPDRS-III pre-off | 0.23 | 0.001 | |
| Duration of PD | 0.47 | 0.042 | |
| Age at surgery | 0.02 | 0.86 | |
|
| |||
| Change in DAB scale pre-on to one year on/on | AIDS pre-on | 0.13 | 0.2 |
| AIDS pre-off | −0.94 | 0.0001 | |
| UPDRS-III pre-on | 0.32 | 0.025 | |
| UPDRS-III pre-off | 0.16 | 0.007 | |
| Duration of PD | 0.43 | 0.014 | |
| Age at surgery | −0.05 | 0.63 | |