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. 2022 Jan 12;219(3):e20210527. doi: 10.1084/jem.20210527

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© 2022 Liu et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 5. — Infant B cells are intrinsically unable to form TI GCs. (A) The protocol. B1-8^hi GFP⁺ cells from adult (8–12 wk) or infant (3 wk) mice were transferred into either adult or infant recipients as indicated, and TI GCs were constructed by i.p. NP₃₀-Ficoll immunization. (B–G) FACS dot plots and summary statistics show TI GCs (B and C), PCs (D and E), and B_mem cells (F and G) in the spleen of recipients, 5 d after immunization. Data were pooled from two independent experiments with at least three mice per group. Each symbol indicates one mouse, and lines denote means. P values by t tests. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.