Figure 2.

Microglia in the M2 anti-inflammatory state. M2 microglia release cytokines that downregulate the inflammatory response and promote tissue repair (A). Their morphology consists of ramified processes that reach out and survey their microenvironment for any tissue damage or inflammatory insult (B). These arms are mobile, as they constantly retract and extend. For energy production, anti-inflammatory and resting microglia rely on oxidative phosphorylation for ATP production (C). Created with BioRender.com.