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. 2022 Jan 14;17(1):e0261675. doi: 10.1371/journal.pone.0261675

Fig 3. Effect of genetic ablation of CYP2E1 on alcohol induced hepatic retinoid metabolism.

Fig 3

Consumption of 6.4% alcohol for 2 weeks significantly decreased hepatic retinol level in wild type (WT) mice but did not affect retinol levels in Cyp2e1-/- mice (A). Total hepatic retinyl ester levels are not significantly different between WT and Cyp2e1-/- mice (B). Consumption of 6.4% alcohol for 2 weeks significantly decreased hepatic retinyl palmitate levels in both WT mice and Cyp2e1-/- mice (C). Consumption of 6.4% alcohol for 2 weeks significantly increased hepatic retinyl oleate level in both WT mice and Cyp2e1-/- mice (D). Consumption of 6.4% alcohol for 2 weeks significantly increased Cyp26a1 expression levels in the WT mice not in the Cyp2e1-/- mice (E). Consumption of 6.4% alcohol for 2 weeks significantly increased Cyp26b1 expression level both in the WT and Cyp2e1-/- mice (F). Data analyzed by Two-way ANOVA; *P <0.05 vs. control for Tukey’s multiple comparison post-test (A-F).