Table 2.

Multivariate Cox proportional hazards models for risk of recurrence, distant metastasis and overall survival for copy number imbalance in LRIG1

Patient or tumor characteristic	Any Recurrence		Distant Metastasis		Overall Survival
	HR (95% CI)	p value	HR (95% CI)	p value	HR (95% CI)	p value
Age, diagnosis (y)
< 50	Reference		Reference		Reference
≥ 50	1.60 (1.24–2.07)	0.0003	1.58 (1.19–2.09)	0.002	0.69 (0.55–0.87)	0.002
Tumor size (cm)
< 2	Reference		Reference		Reference
≥ 2	1.71 (1.33–2.22)	< 0.0001	1.99 (1.50–2.64)	< 0.0001	1.59 (1.28–1.98)	< 0.0001
Lymph node
Negative	Reference		Reference		Reference
Positive	1.62 (1.26–2.10)	0.0002	1.85 (1.39–2.46)	< 0.0001	1.39 (1.12–1.74)	0.003
LRIG1
Copy normal	Reference		Reference		Reference
Loss	1.91 (1.33–2.74)	0.0004	2.10 (1.43–3.09)	< 0.0001	1.55 (1.11–2.16)	0.009
Gain	0.87 (0.43–1.78)	0.71	0.94 (0.44–2.01)	0.87	0.97 (0.56–1.71)	0.93

Abbreviations: HR, hazard ratio; CI, confidence interval

Note: The clinical covariates shown above were chosen using a stepwise selection procedure to minimize Akaike Information Criterion.