Table 1.

The optimisation of conditions for the preparation of compound 9–8.

Entry	Heating	Temp (∘C)	Time (min)	Yield (%)
1a	Oil bath	Reflux	60	Trace
2a	Oil bath	Reflux	360	10c
3a	Oil bath	Reflux	600	30c
4a	Oil bath	Reflux	720	41c
5a	Oil bath	Reflux	960	52d
6b	MW	120	20	45c
7b	MW	130	10	50d
8 b	MW	130	20	67 d
9b	MW	130	30	62d
10b	MW	140	20	60d

^a Reaction conditions: ethyl 2-((3-bromophenyl)amino)-2-oxoacetate (1 mmol), Ph3P (1.5 mmol), CCl4 (5 ml).

^b Reaction conditions: ethyl 2-((3-bromophenyl)amino)-2-oxoacetate (1 mmol), Ph3P (1.5 mmol), CCl4 (5 ml), MW.

^c The yields were determined by HPLC.

^d Isolated yields.