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. Author manuscript; available in PMC: 2022 Jun 20.
Published in final edited form as: Nat Aging. 2021 Dec 20;1(12):1162–1174. doi: 10.1038/s43587-021-00146-z

Extended Data Fig. 2: Generation of Cre-inducible Tert knock-in mouse (R26-CAG-LSL-mTert).

Extended Data Fig. 2:

a, Genotyping results of the original ES targeted lines carrying the R26-CAG-LSL-mTert-IRES-eGFP-pA alleles. b, Representative photographs of chimeric mice obtained from targeted ES cells. c, Aβ immunostaining in the hippocampus of adult (7-month-old) control and Tert-activated R26-CAG-LSL-mTert; 5xFAD; Camk2a-CreERT2 mice. Experiments were repeated three times independently with similar results. Scale bar, 300 μm.