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. 2022 Jan 18;132(2):e150634. doi: 10.1172/JCI150634

Figure 1. Peanut-reactive T cells decrease in frequency over the course of OIT.

Figure 1

(A) OIT study design, sample processing, and patient cohorts. CD3+CD4+CD45RA– memory T cells were sorted by FACS as CD154+CD137+/– (CD154+), CD154–CD137+ (CD137+), or CD154–CD137–. (For clinical outcomes and patient information, see Methods and Supplemental Tables 1 and 2.) (B) Representative flow plots of cells from 1 patient at 1 time point (n = 12 patients total). (C) Percentage of CD4+ memory T cells at each time point that were CD154+ (left) or CD137+ (right) in peanut-stimulated PBMC cultures from patients in the treatment group. *P < 0.05 (adjusted), by paired Wilcoxon rank sum test. AV, avoidance; BL, baseline; BU, buildup; MN, maintenance; PL, placebo; PT, partial tolerance; TF, treatment failure; TO, tolerance.