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. 2022 Jan 7;2022:1125932. doi: 10.1155/2022/1125932

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Copyright © 2022 Feiran Wang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Characterization, transfection efficiency, and in vivo antitumor efficacy of nanoparticle/siRNA complexes. (a) Representative scanning electron microscopy images of the empty nanoparticles and nanoparticle/siRNA complexes; magnification 10,400x. (b) Hydrodynamic diameter distribution of the empty nanoparticles and nanoparticle/siRNA complexes. (c) A gel retardation assay of nanoparticle/siRNA complexes at different N/P ratios. (d, e) Representative fluorescent images, matched bright images, and transfection efficiency of Huh7 cells transfected with empty nanoparticles and nanoparticle/siRNA complexes. (f) The representative images of tumor growth in the subcutaneous xenograft model of Huh7 cells in nude mice. (g, h) In vivo antitumor results revealed the effects of tumor volume and weight after the treatment with nanoparticle/scramble siRNA complexes (scramble) and nanoparticle/AL033381.2 siRNA complexes (AL033381.2 siRNA). ^∗P < 0.05. (i) The relative mRNA expression level of AL033381.2 between the scramble and AL033381.2 siRNA Huh7 cell lines.