Table 4. Diagnostic performance of different classifications able to predict the correct histology using the most frequent answer as reference.

Histology	Category	Sensitivity (%) [95 % CI]	Specificity (%) [95 % CI]
Hyperplastic polyp
	Sano I	93.8 [69.8; 99.8]	82.1 [75.9; 87.3]
	NICE 1	93.8 [69.8; 99.8]	82.6 [76.5; 87.7]
	CONECCT IH	87.5 [61.7; 98.4]	98.9 [96.2; 99.9]
P value		0.045	< 0.001
SSAP
	WASP	90.0 [73.5; 97.9]	98.3 [95.1; 99.6]
	CONECCT IS	90.0 [73.5; 97.9]	98.3 [95.1; 99.6]
P value		1.000	1.000
Adenoma
	NICE 2	91.9 [85.6; 96.0]	71.1 [60.1; 80.5]
	CONECCT IIA	70.7 [61.9; 78.6]	89.2 [80.4 ;94.9]
P value		< 0.001	< 0.001
Superficial adenocarcinoma
	Kudo Vi	31.6 [12.6; 56.6]	93.6 [89.1; 96.6]
	Sano IIIa	63.2 [38.4; 83.7]	87.7 [82.1; 92.0]
	NICE 2	84.2 [60.4; 96.6]	35.3 [28.5; 42.6]
	CONECCT IIC	78.9 [54.4; 93.9]	83.4 [77.3; 88.4]
P value		< 0.001	< 0.001
Deep invasive adenocarcinoma
	Kudo Vn	72.2 [46.5; 90.3]	98.4 [95.4; 99.7]
	Sano IIIb	77.8 [52.4; 93.6]	97.9 [94.6; 99.4]
	NICE III	77.8 [52.4; 93.6]	96.8 [93.2; 98.8]
	CONECCT III	77.8 [52.4; 93.6]	97.9 [94.6; 99.4]
P value		0.108	< 0.001

CI, confidence interval; SSAP, sessile serrated adenoma polyp; NICE, International Colorectal Endoscopic Classification; CONECCT, COlorectal NEoplasia Classification to Choose the Treatment; WASP, Workgroup serrAted polypS and Polyposis.