Table 1.

Monitoring Recommendations for Mucopolysaccharidosis Type IVA Patients

At Diagnosis	Every 6 Mo	Annually	Every 1–3 Yr
Medical history	Medical history	Eye examination	Electrocardiogram
Physical examination	Physical examination	Hearing test	Echocardiogram
Growth evaluation	Growth evaluation	Pulmonary function	Spine MRI
Neurological examination	Neurological examination	Electrocardiogram	Sleep study
Eye examination	Dental evaluation	Echocardiogram
Hearing test		Endurance test
Pulmonary function		Quality of life and pain assessment
Sleep study		Cervical spine imaging
Electrocardiogram
Echocardiogram
Dental evaluation
Endurance test
Quality of life and pain assessment
Functional/ADL assessment
Hip/pelvis imaging
Whole Spine imaging
Spine MRI

Notes: Reproduced with permission from Dove Medical Press, Regier DS, Tanpaiboon P. Role of elosulfase alfa in mucopolysaccharidosis IVA. Appl Clin Genet. 2016;9:67–74.35

Abbreviations: mo, months; yr, years; ADL, activities of daily living.