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. 2021 Jun 22;26(11):6394–6410. doi: 10.1038/s41380-021-01166-2

Fig. 1. BACE1 deficiency causes reductions in synaptic proteins.

Fig. 1

A Hippocampal synaptosomes prepared from 15- and 25-month-old mice were examined on the blot using antibodies as indicated. While levels of most synaptic proteins were not significantly differed between wild type (WT) and BACE1-null samples, mGluR1 and PSD-95 were clearly reduced in BACE1-null samples. B Bar graphs showing a significant change in levels of mGluR1 and PSD-95 in aging mice (N = 3 independent experiments, *P < 0.05; Student’s t test). C Brain lysates from 12-month-old WT and BACE1-null mice were analyzed by antibodies as specified on the western blot. Reduction of complexin, VAMP, and synaptophysin was noted, while BACE1 substrate neuregulin-1 (Nrg1) was elevated due to abolished cleavage. D Bar graphs showed statistical significance (N = 4, **P < 0.01, *P < 0.05, Student’s t test).