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. 2021 Jun 22;26(11):6394–6410. doi: 10.1038/s41380-021-01166-2

Fig. 3. mGluR1-positive allosteric modulators LTP in BACE1-null or inhibited mice.

Fig. 3

A LTP was recorded on horizontal hippocampal slices from about 6-month-old BACE1-null (KO) mice treated with mGluR1-PAM Ro0711401 at 10 mg/kg, injected 1 h before sacrificing and harvesting acute brain slices. B BACE1-null (BACE1−/−) slices were treated with CHPG at 125 nM before high-frequency stimulation during LTP recording, which elicited a significantly improved LTP response when compared to mock-treated BACE1-null brain slices (N = 8 for BACE1−/−, and N = 11 for BACE1−/− + Ro0711401 and N = 10 for BACE1−/− + CHPG; **P < 0.01, Student’s t test). CHPG treatment markedly improved LTP in mice treated with Verubecestat at 3 mg/kg (C), but less in mice treated with Lanabecestat at 0.5 mg/kg (D). (N = 8–10; **P < 0.01; ***P < 0.001; Student’s t test).