Skip to main content
. 2021 Jun 22;26(11):6394–6410. doi: 10.1038/s41380-021-01166-2

Fig. 5. mGluR1-positive allosteric modulator reverses impaired cognitive behaviors by the BACE1 inhibition.

Fig. 5

A, B Administration of mGluR1 PAM Ro67-7476 improved the number of % spontaneous alteration in Y-maze task when given in mice treated with BACE1 inhibitors Lanabecestat or Verubecestat. Unlikely seen in BACE1-null mice, the number of total entries was markedly reduced in mice treated with these two inhibitors. C–E These mice were also tested on the open filed tasks. A marked reduction in the total distance covered and average speed in the open field in the combined treatment group of mgluR1 PAMs and BACE1 inhibitors vs only BACE1 inhibitors. The heat maps in E showed improved anxiety behaviors in BACE1-inhibited mice (N = 10 in BACE1+/+, 10 in BACE1+/+ + Lanabecestat, 10 in BACE1+/+ + Verubecestat, 9 in BACE1+/+ + Lanabecestat + Ro67-7476, and 10 in BACE1+/+ + Verubecestat + Ro67-7476: **P < 0.01; ***P < 0.01; Student’s t test).