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. 2021 Jun 22;26(11):6394–6410. doi: 10.1038/s41380-021-01166-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A Representative EM images show different active zones and synaptic vesicles in the presynaptic compartment of WT control (BACE1^+/+), in BACE1 deficient mice BACE1^−/−, or BACE1^+/+ mice with Lanabecestat or Verubecestat. B, C Active zone lengths and their cumulative frequency histogram in above conditions were quantified. D Number of docked vesicles (within 5 nm from presynaptic membrane) per active zone. E Synaptic vesicle distribution up to 200 nm distance from presynaptic membrane (constituting RRP) of the active zone (N = 3 animals in each group, 87 randomly selected active zones or 60 synapses were analyzed; ***P < 0.001, unpaired Student’s t test).