Skip to main content
. 2021 Jun 22;26(11):6394–6410. doi: 10.1038/s41380-021-01166-2

Fig. 7. mGluR1 PAM treatment impacts active zone length.

Fig. 7

A Representative EM images show synaptic structures in WT mice treated with mGluR1 PAM Ro677467 together with Lanabecestat or Verubecestat. B, C Active zone lengths and their cumulative frequency histogram were quantified and compared among four treated groups and WT like above and show a relatively increase in size in the animals treated with BACE1 inhibitors alone or in combination with PAMs. D Number of docked vesicles (within 5 nm from presynaptic membrane) per active zone is also significantly decreased. E Synaptic vesicle distribution up to 200 nm distance from presynaptic membrane of active zone is also impacted in the groups with BACE1 inhibitor treatments (N = 60, ***P < 0.001, Student’s t test).