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. 2021 May 17;26(11):6756–6772. doi: 10.1038/s41380-021-01145-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Total distance moved and time spent in the center zone of the open field test in male offspring. **p < 0.01, reflecting the main effect of SIR; ^##p < 0.01, reflecting the main effect of FLX treatment. b Total distance moved and time spent in the center zone of the open field test in female offspring. ***p < 0.001, reflecting the main effect of SIR. c Total distance moved and percent exploration time of an unfamiliar mouse compared to a dummy object in the social interaction test in male offspring. d Total distance moved and percent exploration time of an unfamiliar mouse compared to a dummy object in the social interaction test in female offspring. e Relative exploration time (%) of the novel arm in the Y-maze test of spatial recognition memory in male offspring. °°p < 0.01 between SIR-VEH and SIR-FLX; *p < 0.05 between SIR-VEH and GRP-VEH. f Relative time (%) spent exploring the remote object in the temporal order memory test in male offspring; °p < 0.05 between SIR-VEH and SIR-FLX; *p < 0.05 between SIR-VEH and GRP-VEH. g Relative exploration time (%) of the novel arm in the Y-maze test of spatial recognition memory in female offspring. h Relative time (%) spent exploring the remote object in the temporal order memory test in female offspring. i Time spent immobile in the forced swim test (FST) test in male offspring. j Basal and FST-induced levels of CORT in male offspring. *p < 0.05 between SIR-VEH and GRP-VEH; ^§§§p < 0.001 between SIR-FLX vs SIR-VEH. k Time spent immobile in the forced swim test (FST) test in female offspring. ^#p < 0.05, reflecting the main effect of FLX treatment. l Basal and FST-induced levels of CORT in female offspring. **p < 0.01 between SIR-VEH and GRP-VEH; N = 10.11 mice per group and sex in a–h, N = 12-13 animals per group and sex in i–l. All values represent means ± s.e.m.