Table 1.
Summary of the effects maternal SIR and FLX treatment on the dams and their offspring.
| Test | Maternal behavior | Offspring behavior | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Males | Females | |||||||||||
| Grouped | SIR | Grouped | SIR | Grouped | SIR | |||||||
| VEH | FLX | VEH | FLX | VEH | FLX | VEH | FLX | VEH | FLX | VEH | FLX | |
| Anxiety | ||||||||||||
| Light-Dark box | ||||||||||||
| Latency | = | NA | ↑ | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Open-field | ||||||||||||
| % Time in Centre Zone | = | = | ↓ | ↓ | = | ↑ | ↓ | ↑ | = | = | ↓ | ↓ |
| Social behavior | ||||||||||||
| Social Interaction | ||||||||||||
| % Time interacting with live mouse | = | = | ↓ | = | = | = | = | = | = | = | = | = |
| Cognitive function | ||||||||||||
| Temporal order memory test | ||||||||||||
| % Time with remote object | NA | NA | NA | NA | = | = | ↓ | = | = | = | = | = |
| Y-maze | ||||||||||||
| % Time in the novel arm | NA | NA | NA | NA | = | = | ↓ | = | = | = | = | = |
| FST | ||||||||||||
| Forced swim test | ||||||||||||
| Time spent immobile | = | = | ↑ | = | = | = | = | = | = | ↓ | = | ↓ |
| CORT | ||||||||||||
| Basal CORT | = | = | ↓ | ↓ | = | = | = | = | = | = | = | = |
| Post-FST CORT | = | = | ↓ | ↓ | = | = | ↑ | = | = | = | ↑ | = |
NA not applicable, animals not tested in these behaviors, = Control level and no change compared to CON-VEH, ↑ Increased measure compared to CON-VEH, ↓ Decreased measure compared to CON-VEH.