Table 4.

Suggested best practice model: Plausible fertility preservation and restoration strategies for breast cancer patients

Cancer Patients	Before anticancer therapy (Fertility Preservation)	During anticancer therapy (Fertility Preservation)	After anticancer therapy (Fertility Restoration)
Breast Cancer Patients with or without BRCA mutations	- Egg freezing - Embryo freezing - Ovarian tissue freezing - In vitro maturation (IVM) of oocytes and vitrification - Artificial ovary technology (promising in research but not yet clinically proven)	- GnRH analogs - Fractionation of chemo- and radiotherapy - Ovarian shielding in case of combined pelvic irradiation - Neoadjuvant cytoprotective pharmacotherapy (promising in research but not yet clinically proven)	- Intrauterine transfer of frozen embryo - IVF/ICSI of frozen oocytes - Autotransplantation of frozen ovarian tissue (should be utilized with caution in BRCA mutations) - Stem cells (promising in research but not yet clinically proven)