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. 2022 Jan 15:1–30. Online ahead of print. doi: 10.1007/s10479-021-04347-y

Table 6.

Direct and indirect effects of criteria in each cluster

Criteria (R + C) (R − C)
CTR1: Scientific approach and technology used
7 Coverage of different technologies 15.01012977  − 1.069650646
11 Individuals included in vaccine trials 15.71545595 0.767706886
13 Vaccine regulation 15.3660784  − 0.732049227
21 Sourcing of appropriate expertise 13.30900535 1.327549866
41 No serious side effects 15.08626407  − 0.293556879
CTR2: Speed of delivery
52 Speed of processes 19.71803677  − 1.228229698
53 Progress in clinical trials 19.11957218 0.018927311
54 Estimated time to market in 2020 and 2021 17.89725139 0.309802989
55 Application for marketing authorizations 19.78167492 0.640193116
56 Reduced outbreaks 19.56403032 0.682856467
57 Avoidance of misinformation 19.17961015  − 1.290898621
59 Extensive testing of safety and effectiveness 19.39656537 0.867348437
CTR3: Cost
19 Rigorous analysis of results 12.78867858 1.619404715
61 Production cost 12.89344839 0.502080687
62 Payment terms 13.80189928  − 0.691757682
63 Payment schedule 12.72568174  − 0.553306233
104 Testing and evaluation before licensing by Food and Drug Administration 12.36781638  − 0.876421487
CTR4: Liability and risk sharing
67 Benefits offered by financing provided 16.65697865  − 0.84739254
68 Final purchase conditions 15.86153375  − 0.248925465
69 Liability terms 17.65648392 0.219894345
70 Commitment to regulators 15.94897471  − 0.583497016
72 Vaccination ethics 17.35307759 0.014091765
75 Vaccine injury compensation 15.58030584  − 0.122424521
78 Post-research immunization schedule 13.42471281 1.568253432
CTR5: Ability to supply sufficient quantities through production capacity development
43 Global production capacity 13.04860795  − 0.147709773
44 Production capacity without disruptions 14.57094816  − 0.12889826
46 Mitigation of supply chain disruptions 13.52509107  − 0.679156463
47 Consistent ability to manufacture 14.263633  − 0.51660328
48 Vaccine production facilities 14.3857391 0.871495514
49 Safest vaccine supply to date 13.2375538  − 0.516982925
50 Every vaccine batch tested 11.90515624 1.117855186
CTR6: Global solidarity
85 Vaccine tests in vulnerable populations 21.80083619  − 0.166287667
91 Vaccine supply for world’s poorest countries 21.96719102  − 1.481635453
92 Equitable access to vaccines in emergencies 21.75202149 1.92394612
93 Vaccine provision for financially disadvantaged individuals 21.82751528 0.092452284
94 No racism or other forms of discrimination 21.22157512  − 0.879315539
102 Education about vaccination value 22.24485781 0.375208736
103 Vaccination status checks among school children 22.80895714 0.13563152