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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Trends Biochem Sci. 2021 Jul 16;47(2):124–135. doi: 10.1016/j.tibs.2021.06.008

Figure 2, Key Figure: High-resolution cryoEM maps of a wide variety of membrane protein drug targets.

Figure 2, Key Figure:

This includes G protein-coupled receptors (GPCRs) and transporters (top row) and ion channels (bottom row), with an example FDA-approved ligand for each receptor (blue boxes). PDB IDs and resolution provided below protein name. Membrane generated with CHARMM-GUIviii [62] and figure rendered in ChimeraXix [63]. GABAA (PDB ID 6HUG) and TRPV5 (PDB ID 6O1U) were determined in lipid nanodiscs; all others displayed were obtained in detergent micelles.