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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Trends Biochem Sci. 2021 Jul 16;47(2):124–135. doi: 10.1016/j.tibs.2021.06.008

Figure 3: Demonstration of the utility of cryoEM for both small-molecule and biologics discovery.

Figure 3:

CryoEM maps of (A) the insulin receptor bound to insulin (PDB ID 6PXV) and (B) CD20 in complex with rituximab Fabs (PDB ID 6VJA). (C) Accurate modeling of PETG into a cryoEM map of β-galactosidase using GemSpot (PDB ID 6CVM). (D) Fragment-based discovery for PKM2 with cryoEM density allowing for correct identification and placement of discovery fragment (PDB ID 6TTF).